Targeting PAK1
نویسندگان
چکیده
منابع مشابه
MicroRNA-494 inhibits breast cancer progression by directly targeting PAK1
MicroRNA (miRNA) is involved in the progression and metastasis of diverse human cancers, including breast cancer, as strong evidence has been found that miRNAs can act as oncogenes or tumor suppressor genes. Here, we show that miR-494 is decreased in human breast cancer specimens and breast cancer cell lines. Ectopic expression of miR-494 in basal-like breast cancer cell lines MDA-MB-231-LUC-D2...
متن کاملTaming the wild-types: targeting PAK1 in melanomas that lack BRAF mutations.
Remarkable progress has been made recently in identifying the molecular drivers of melanomagenesis. High-throughput genomic screening has revealed melanoma to be a diverse collection of tumors initiated by distinct oncogenes (1). About half of all cutane-ous melanomas have activating mutations in the serine/threonine kinase BRAF that drives tumor initiation and progression through the mitogen-a...
متن کاملTargeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells.
p21-activated kinases (PAKs) are serine/threonine protein kinases that serve as important mediators of Rac and Cdc42 GTPase function as well as pathways required for Ras-driven tumorigenesis. PAK1 has been implicated in signaling by growth factor receptors and morphogenetic processes that control cell polarity, invasion, and actin cytoskeleton organization. To better understand the role of PAK1...
متن کاملMembrane targeting of p21-activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cells.
Rho-family GTPases regulate cytoskeletal dynamics in various cell types. p21-activated kinase 1 (PAK1) is one of the downstream effectors of Rac and Cdc42 which has been implicated as a mediator of polarized cytoskeletal changes in fibroblasts. We show here that the extension of neurites induced by nerve growth factor (NGF) in the neuronal cell line PC12 is inhibited by dominant-negative Rac2 a...
متن کامل1α,25(OH)2D3 Induces Actin Depolymerization in Endometrial Carcinoma Cells by Targeting RAC1 and PAK1.
BACKGROUND Cell proliferation and motility require actin reorganization, which is under control of various signalling pathways including ras-related C3 botulinum toxin substrate 1 (RAC1), p21 protein-activated kinase 1 (PAK1) and actin related protein 2 (ARP2). Tumour cell proliferation is modified by 1α,25-Dihydroxy-Vitamin D3 (1α,25(OH)2D3), a steroid hormone predominantly known for its role ...
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ژورنال
عنوان ژورنال: Biochemical Society Transactions
سال: 2017
ISSN: 0300-5127,1470-8752
DOI: 10.1042/bst20160134